Monthly Archives: June 2009

Disrupting Disordered Neurocircuitry: Treating Refractory Psychiatric Illness With Neuromodulation

Dr. Kendall Lee discusses a review article addressing the use of Deep Brain Stimulation for treating depression, obsessive-compulsive disorder, and Tourette syndrome.
This reveiw article appeared in the July issue of Mayo Clinic Proceedings journal.

Abstract
Despite the premature and somewhat infamous rise and fall of psychosurgery in the mid-20th century, the current era of functional neuromodulation proffers [...]

Enteral stenting and new technology

Dr. Todd Baron discusses Mayo Clinic’s use of self-expandable metal stents
Self-expandable metal stents (SEMS) are now acceptable for use in the gastrointestinal tract to relieve malignant luminal obstruction.
SEMS are used as an alternative to surgical bypass for palliation of malignant gastric-outlet obstruction, in the upper gastrointestinal tract.
In the colon, SEMS are used to avoid colostomy [...]

Managing patients with myelofibrosis

Dr. Ruben Mesa discusses myelofibrosis management
Managing patients with myelofibrosis (MF) – both those with primary myelofibrosis (PMF), or MF that has evolved from antecedent polycythemia vera or essential thrombocythemia (Post PV/ET MF) – presents many challenges to the hematologist.
MF patients suffer from a range of debilitating disease manifestations, including massive splenomegaly, cytopenias, constitutional symptoms, and [...]

Robotic Mitral Valve Repair Safe, Durable

Dr. Rakesh Suri dicusses mitral valve repair outcomes at Mayo Clinic.
Mitral regurgitation is a clinically challenging condition because it can be asymptomatic early on. Most patients at the time of diagnosis are young and otherwise healthy. Data show that medical management of severe mitral regurgitation results in excess mortality. The traditional surgical treatment has been [...]

Fracture Risk after Bariatric Surgery

Elizabeth Haglind, M.D., endocrinologist discusses a Mayo Clinic study recently presented at the 2009 Endocrinology Society Annual Meeting in Washington, D.C.
Abstract
Introduction: There is a dramatic and sustained increase in bone turnover following bariatric surgery. However the impact on fracture rates is unknown. We hypothesized that accelerated bone turnover would increase fracture risk following bariatric surgery. The [...]

Treatment of Carotid Artery Stenosis: Medical Therapy, Surgery, or Stenting?

Dr. Giuseppe Lanzino discussed treatment options for patients diagnosed with partially blocked carotid arteries but without symptoms such as a mini-stroke, or amaurosis fugax. 
 
Dr. Lanzino worked with Mayo Clinic neurologists Alejandro Rabinstein, M.D., and Robert D. Brown, M.D., to review the most current studies dealing with the medical, surgical, and endovascular treatment of carotid artery [...]

A Multivariable Model Using Advanced Cytologic Methods for the Evaluation of Indeterminate Pancreatobiliary Strictures

Dr. Lewis Roberts explains new tests that double the ability to detect bile duct and pancreatic cancers. This Mayo Clinic study was published in the June issue of Gastroenterology.
ABSTRACT
Background & Aims: Ancillary cytologic tests including digital image analysis (DIA) and fluorescence in situ hybridization (FISH) have been developed to improve the sensitivity of routine cytology [...]

Final results of NCCTG N0489: Epratuzumab and rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (ER-CHOP) in patients with previously untreated diffuse large B-cell lymphoma.

Dr. Ivana Micallef, working with the North Central Cancer Treatment Group, discusses a new Mayo Clinic study that shows when combined with a cocktail of chemotherapy drugs, two monoclonal antibodies, instead of one, appear to offer superior results in patients with diffuse large B-cell lymphoma. The study was presented at the 2009 annual meeting of [...]

Pan-Detection of Gastrointestinal Neoplasms by Stool DNA Testing: Establishment of Feasibility

Dr. David Ahlquist discusses how Mayo Clinic researchers have demonstrated that a noninvasive screening test can detect not only colorectal cancer but also the common cancers above the colon — including pancreas, stomach, biliary and esophageal cancers. This study was presented at the Digestive Disorders Week 2009 meeting.

ABSTRACT:
Gastrointestinal (GI) cancers account for approximately 1 in [...]